1. Preheat the oven to 350°F.
2. Cut each biscuit into quarters.
3. In a large zip-top bag, combine granulated sugar and pumpkin pie spice. Add half of the biscuit pieces, seal the bag, and shake well to coat. Place the coated pieces in an even layer in a 10-cup Bundt pan. Repeat with remaining biscuit pieces and sugar mixture.
4. In a medium saucepan over medium heat, melt the butter and brown sugar, stirring until the sugar is mostly melted, about 2 to 3 minutes.
5. Whisk in the heavy cream and pumpkin puree. Bring to a simmer and cook, stirring frequently, until well combined and slightly thickened, 3 to 5 minutes.
6. Remove from heat and whisk in vanilla bean paste.
7. Pour the warm pumpkin caramel mixture evenly over the biscuit pieces in the Bundt pan.
8. Bake for 45 to 50 minutes, until golden brown and bubbling.
9. Let cool in the pan for 10 minutes, then invert onto a serving plate. Serve warm.